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Immunologic memory and protective immunity: understanding their relation. Los Alamos National Laboratory.

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Plummer, GR; F. Plummer, RF National Center for Biotechnology InformationProstitutes Nacka. Journal List J Clin Invest v. J Clin Invest.

Rupert Kaul1, Prostitutes Nacka Sarah L. Bwayo1 Kelly S. MacDonald3 Andrew J. McMichael2 and Francis A. Plummer 1, 4. Sarah L. Job J. Kelly S. Andrew J. Francis A. Author information Article notes Copyright and License information Disclaimer. Phone: ; Prostitutes Nacka ; E-mail: moc. Received Jul 6; Accepted Dec This article has been cited by other articles Prostitutes Nacka PMC. Introduction Individuals exhibit different susceptibility to infection by HIV-1, with a minority of individuals remaining uninfected despite repeated viral exposure 1 — 3.

Methods Study populations and general laboratory methods. HIV-1 epitope selection and peptide synthesis. CTL bulk cultures. HIV-1 epitope Prostitutes Nacka. Case-control study.

Data analysis. Results Preceding HIV-1 epitope—specific responses in seroconverters. Open in a separate window. Figure 1.

Case-control analysis. Table 3 Case-control comparison of late seroconverters with enrollment-matched controls remaining HIV-1 seronegative. HIV-1 epitope responses in persistently seronegative controls. Figure 2. Discussion Despite intense HIV-1—infection pressure, a small Prostitutes Nacka of sex workers in Nairobi, Kenya, have remained Prostitutes Nacka for periods of up to 15 years Figure 3.

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Acknowledgments We thank Jane Prostitutes Nacka for assistance in subject recruitment; Kati di Gleria for peptide synthesis; and the women of the Pumwani cohort for their cooperation and enthusiasm. References 1.

Clerici M, Shearer GM. Immunol Lett. Toward an understanding of the correlates of protective immunity to HIV infection.

Immune responses in HIV-exposed seronegatives: have they repelled the virus? Curr Prostitutes Nacka Immunol. Letvin NL. Progress in the development of an HIV-1 vaccine. Ogg GS, et al. Decay Prostitutes Nacka of human immunodeficiency virus-specific effector cytotoxic T lymphocytes after combination antiretroviral therapy. J Virol. Nixon DF, et al.

Molecular tracking of an Human Immunodeficiency Virus nef specific cytotoxic T-cell clone shows persistence of clone-specific T-cell receptor DNA but not mRNA following early combination antiretroviral therapy. Dalod M, et al. Evolution of cytotoxic T lymphocyte responses to human immunodeficiency virus type 1 in patients with symptomatic primary infection receiving antiretroviral triple therapy.

Prostitutes Nacka Infect Dis. Kalams SA, et al. Levels of human immunodeficiency virus type 1-specific cytotoxic T-lymphocyte effector and memory responses decline after suppression of viremia with highly active antiretroviral therapy. Gray CM, et al. McMichael AJ, et al. Pinto LA, et al. Fowke KR, et al. Immunol Prostitutes Nacka Biol. Goh WC, et al. Protection against human immunodeficiency virus type 1 infection in persons with repeated exposure: evidence for T cell immunity in the absence of inherited CCR5 coreceptor defects.

Rowland-Jones S, et al. Nat Med. Rowland-Jones Prostitutes Nacka, et al. Prostitutes Nacka, R. Korber et al. Prostitutes Nacka Alamos National Laboratory. Kundig TM, et al. On the role of antigen in maintaining cytotoxic T-cell memory.

Mortara L, et Prostitutes Nacka. Selection of virus variants and emergence of virus escape mutants after immunization with an epitope vaccine.

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Borrow P, et al. Escape of human immunodeficiency virus from immune control. Annu Rev Immunol. Price DA, et al. Positive selection Prostitutes Nacka HIV-1 cytotoxic T lymphocyte escape variants during primary infection. HIV type 1 resistance in Kenyan sex workers is not associated with altered cellular susceptibility to HIV type 1 infection or enhanced beta-chemokine production.

MacDonald KS, et al. Influence of Prostitutes Nacka supertypes on susceptibility and resistance to human immunodeficiency virus type 1 infection. Kaul R, et Prostitutes Nacka. J Immunol. Ngugi EN, et al. Prevention of transmission of human immunodeficiency virus in Africa: effectiveness of condom promotion and health education among prostitutes.

The mean number of epitopes screened in lower-risk women was 5.

Simonsen JN, et al. HIV infection among lower socioeconomic strata prostitutes in Nairobi. Development of oligonucleotide primers and Prostitutes Nacka against structural and regulatory genes of human immunodeficiency virus type 1 HIV-1 and their use for amplification of HIV-1 provirus by using polymerase chain reaction.

J Clin Microbiol. Bunce M, et al. Resistance to HIV-1 Prostitutes Nacka among highly exposed sex workers in Nairobi: what mediates protection and Prostitutes Nacka does it develop?

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Martin HL, Jr, et Prostitutes Nacka. Preparation for AIDS vaccine evaluation in Mombasa, Kenya: establishment of seronegative cohorts of commercial sex workers and trucking company Prostitutes Nacka. Larsson M, et al. Ahmed R, Gray D. Immunologic memory and protective immunity: understanding their relation.